How to Synthesize Cocaine: The Illicit Chemical Process

Cocaine production is an illegal and dangerous process involving complex chemical reactions. This article examines the methods used to synthesize cocaine from coca plants, based on scientific research. The information is provided for educational purposes only - manufacturing cocaine is strictly illegal.

Coca Plant Cultivation

Cocaine synthesis begins with growing coca plants, primarily Erythroxylon coca. These shrubs are native to western South America and thrive in tropical mountain climates. Coca plants require:

  • Warm temperatures (20-30°C)
  • High humidity
  • Acidic soil (pH 5-6)
  • Elevation of 500-2000 meters

Coca seedlings take 12-24 months to mature. Once ready, leaves are harvested multiple times per year. A typical coca field yields 1-4 metric tons of dried leaves annually.

Extracting Coca Paste

The first step in processing is extracting coca paste from dried leaves:

Step 1: Shred dried coca leaves and mix with water and an alkaline substance like lime.

Step 2: Add a hydrocarbon solvent such as kerosene to the mixture. This extracts the cocaine alkaloids.

Step 3: Drain off the kerosene layer containing dissolved cocaine.

Step 4: Add dilute sulfuric acid to the kerosene to convert cocaine to water-soluble cocaine sulfate.

Step 5: Separate out the acidic water layer and add lime or ammonia to precipitate coca paste.

This crude paste contains 40-50% cocaine along with other alkaloids.

Purifying Cocaine Base

Next, the coca paste is refined into cocaine base:

Step 1: Dissolve coca paste in dilute sulfuric acid.

Step 2: Add potassium permanganate to oxidize impurities.

Step 3: Filter the solution and add ammonia to precipitate purified cocaine base.

Step 4: Filter and dry the cocaine base, which is about 80-90% pure cocaine.

Converting to Cocaine Hydrochloride

The final step creates the powdered cocaine hydrochloride salt:

Step 1: Dissolve cocaine base in ether, acetone or other solvents.

Step 2: Bubble hydrogen chloride gas through the solution.

Step 3: Filter and dry the precipitated cocaine hydrochloride crystals.

The resulting powder is typically 80-90% pure cocaine hydrochloride.

Health and Legal Risks

Cocaine production involves numerous hazards:

  • Toxic chemical exposure
  • Risk of fire/explosion
  • Severe legal penalties if caught
  • Potential for addiction when handling product

Cocaine synthesis requires specialized knowledge and equipment. Attempting amateur production is extremely dangerous.


Cocaine manufacture remains a major illegal industry, especially in South America. However, it carries immense risks to human health, the environment, and society. This overview is intended solely to explain the chemical process, not encourage illegal activity.